NFL Week 2 Best Bets

September 17, 2021

clock
12:20 AM ET Sep 20
Chiefs vs Ravens
Chiefs -3.5
-110
Bet
Jay
Jay
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5:00 PM ET Sep 19
49ers vs Eagles
Eagles +3
-110
Caesars
TJ
TJ
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clock
8:00 PM ET Sep 19
Cardinals vs Vikings
Cardinals -3.5
-110
Bet
TJ
TJ
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The best NFL betting picks for Week 2. Here you will find which team to look to when making your wagers for Week 2. 

San Francisco 49ers -3 at Philadelphia Eagles

1PM EST at Lincoln Financial Field

✅ The 49ers travel to the Eastern time zone for the second consecutive week, for an early kickoff. This was an extremely unkind way for the schedule makers to start them off this season. 

✅ The 49ers are already reeling from injuries, and Raheem Mostert being lost for the year is not even the most significant injury they suffered in Week 1. Also lost for the year is top corner Jason Verrett. He was the glue holding the secondary together, and they have no personnel based recourse to account for that loss. 

✅ The Eagles were dominant against the Falcons in Week 1. A huge part of that success was the play of quarterback Jalen Hurts and his wide receivers. Both Jalen Reagor and Devonta Smith found the end zone last week, and the 49ers are going to have massive difficulties trying to cover the duo of first round draft picks. 

The Pick: Eagles +3

Minnesota Vikings at Arizona Cardinals -3.5

4:05 PM EST at State Farm Stadium

✅ The Cardinals offense was electric in Week 1. It would appear Kyler Murray and the rest of the offense is poised for another step forward in 2021, this time entering the echelon of the elite. There is essentially no scoring cap for the Cardinals in this juicy matchup. 

✅ The Vikings were unable to run the ball effectively in Week 1 against the Bengals. That matchup was against a lesser defensive front than the one they face this week. If that trend continues and the Viking offense can't chew some clock and keep the Cardinal offense off the field, this could turn into a blowout. 

✅ The Vikings defense was horrid and injury riddled in 2020, and 2021 is starting out exactly the same. There is not a strength and the defense was torched at all levels in Week 1. Now their best players are injured and not practicing once again. There will be little resistance for the Cardinals elite offense. 

The Pick: Cardinals -3.5

Kansas City Chiefs -3.5 at Baltimore Ravens

8:20PM EST at M&T Bank Stadium

✅ The Chiefs were impressive and mightily resilient in Week 1. They overcame a deficit against the Browns, who are only slightly arguably the best suited team in the league when it comes to protecting an existing lead. The trio of Patrick Mahomes, Travis Kelce and Tyreek Hill remains a cheat code against the rest of the league. 

✅ If and when the Ravens offense is forced to play from behind or have a pass heavy game script for any reason, they are going to continue to struggle. For all of his strengths, Lamar Jackson continues to be an inaccurate passer. He will be unable to bring his team back in spots in which they face a deficit. 

✅ The loss of cornerback Marcus Peters was on display in Week 1, and that was against the lesser wide receiving corps of the Raiders. Of course the Chiefs are a different animal, and there will be problems trying to contain their elite skill position players. 

The Pick: Chiefs -3.5
TJ
TJ Calkins
TJ Calkins was raised in a gambling loving household. He knew how to handicap horse races and follow line movements well before his tenth birthday. While sports betting remained a passion into adulthood, poker and Daily Fantasy Sports also became passions and remain as such today.