Louisville Cardinals vs. Pittsburgh Panthers Betting Picks

September 21, 2020

The 1-1 Louisville Cardinals will go on the road Saturday to face off with the 2-0 Pittsburgh Panthers at 12:00 PM ET in Heinz Field. The Cardinals are coming off a disappointing loss to the Miami Hurricanes while the Panthers have blown both of their opponents out of the water. 

The Cardinals look to hold onto their top-25 ranking while the Panthers look to get into the top-15. Let’s dive into how this one will go.

When The Louisville Cardinals Have The Ball

The Hurricanes got off to a quick start against Louisville and it was a night of big plays. RB Cam’Ron Harris controlled the pace and he exploded with a 75-yard TD to open third-quarter scoring. D’Eriq King connected with Jaylon Knighton on a 75-yard TD to follow and the Cardinals were never able to make it close. 

They weren’t bad offensively, as Malik Cunningham threw for 307 yards and three TD’s while RB Javian Hawkins ran for 164 and a score. The problem was the defense, who allowed 485 total yards without forcing a single turnover. They also gave up three touchdowns on drives five plays or less.  It was definitely a strange game as the Cardinals possessed the ball for nearly double the amount of time while never holding a lead. 

They get a much different challenge in the Pittsburgh Panthers this weekend, who present one of the best defenses in the nation. They’ve allowed a combined 10 points through two games and the combo of Cunningham and Hawkins will face their toughest test to date. Don’t expect to see them move the ball with ease as they did in the first two weeks of the season. 

If Louisville wants to win this game, they’ll have to assert themselves early on the ground. The Panthers pass defense is simply elite and I don’t see Cunningham having the time to throw if they don’t get the running game going first. It’s certainly possible as Louisville has an elite offensive lineman and one of the best running backs in the country running behind it. 

Defensively, Louisville cannot make the same mistakes they did a week ago. The offense has no chance of making up for the points against this defense and they need to strap in for a dog fight. The Panthers will run the ball a bit but employ a spread attack that keeps defenses guessing. 

Wide receiver Tutu Atwell is one the best in the country and he has 192 yards and two touchdowns through two weeks. No matter how good this secondary is, Atwell is individually better and you can expect Cunningham to target him heavily in this matchup when he does drop back. 

When The Pittsburgh Panthers Have The Ball

The Panthers opened the season up with a commanding 55-0 win over the Austin Peay Governors. While that doesn’t seem very impressive, that same team went into 13th ranked Cincinnati and put up 20 points a week later. This defense is for real. 

They followed that performance up with a 21-10 win over the Syracuse Orange, who gave North Carolina a test a week prior. The Panthers held Syracuse to just 171 yards of total offense with most of that coming on a 69-yard TD that was a result of blown coverage. The Orange averaged a brutal 1.5 yards per carry on the ground and were tackled in the backfield six times. 

The Panthers defense wins them games and the offense does it’s best to not lose them. QB Kenny Pickett is nothing extraordinary, but he does a good job of taking care of the ball and getting it into the playmakers’ hands. He threw for 215 yards and two touchdowns against Syracuse with one interception. He ran for another score.

Vincent Davis and A.J. Davis split time at running back and keep each other fresh. Vincent is more of a pass-catcher and speedster while A.J. is more of a downhill runner. At wideout, look for Jared Wayne and Jordan Addison to see a bunch of targets followed by Shocky Jacques-Louis. Coaches have raved about the ladder and I wouldn’t be surprised to see a breakout game before long. 

Defensively, it was a big question whether or not this team would continue to dominate after Jaylen Twyman opted out. He’s a future 1st rounder and was going to be the best player on the team. Edge rushed Rashad Weaver stepped up in a massive way against Syracuse with seven total tackles and two sacks. This defense will continue to work together to replace Twyman.  

Spread Prediction

The Pick: Louisville +3

I like the Louisville Cardinals to bounce back and win this game as a slight underdog. They have the much better offense and this game will come down to how the Cardinals are able to move the ball against the elite Panthers defense. They’ve only allowed 10 points in two games, but haven’t been tested by an elite offense. 

The Cardinals were terrible defensively against Miami, but they still put up more yards than the Hurricanes and looked great offensively. I expect that Hurricane offense to be a top-10 group by year’s end and for that loss to look fine. The loss of Jaylen Twyman is going to eventually show up and I think it does this week. Look for Louisville to assert themselves on the ground to open things up for Cunningham and Atwell through the air.

The Panthers offense is far from explosive and this Cardinals defense won’t be surprised after chasing around D’Eriq King a week ago. The keyword in this game is discipline. The Cardinals are the better team if they don’t make mistakes and that’s exactly what I expect to happen as they fear dropping below .500. 

  • New
    nj
  • 1200px
    pa
  • 1200px
    mi
  • 1200px
    wv
  • Indiana
    in
  • 1200px
    co
  • Illinois
    il
  • State
    tn
  • Seal
    va
  • Iowa
    ia
  • Seal
    dc
  • Other
  • Wide range of banking options
  • Great reward program
  • Well know brand

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Generous bonus offers
  • Wide range of betting options
  • Strong presence in US

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Great promotions
  • Best Multi interface platform
  • Easy registration process

Get $1000 bonus

Promo Сode:
USSBRF1000

Bet365 Sportsbook

Rated 4.8 stars out of 5
4.8
  • World biggest sportsbook
  • Top class user experience
  • Great live betting

Get $500 bonus

Promo Сode:
USSB500
  • Wide Range of Banking Options
  • Great Loyalty Program
  • Generous Bonus

Get $250 bonus

Promo Сode:
USSB
  • Strong presence in US
  • Generous bonus offers
  • Wide range of betting options

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Easy registration process
  • Best Multi interface platform
  • Great promotions

Get $1000 bonus

Promo Сode:
USSBRF1000
  • Great Loyalty Program
  • Generous Bonus
  • Wide Range of Banking Options

Get $250 bonus

Promo Сode:
USSB

Unibet Sportsbook

Rated 4.7 stars out of 5
4.7
  • Trustworthy brand
  • Sign-up Bonus
  • Great international betting coverage

Get $500 bonus

Promo Сode:
NONE NEEDED
  • Offers Casino, Sportsbook & DFS
  • Great Promotions
  • One of the Largest Gambling Sites in the US

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Wide range of banking options
  • Great reward program
  • Well know brand

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Wide range of betting options
  • Strong presence in US
  • Generous bonus offers

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Great promotions
  • Best Multi interface platform
  • Easy registration process

Get $1000 bonus

Promo Сode:
USSBRF1000
  • One of the Largest Gambling Sites in the US
  • Offers Casino, Sportsbook & DFS
  • Great Promotions

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Both online and land-based sportsbook
  • Great Welcome Bonus
  • Top Class Customer Support

Get $250 bonus

Promo Сode:
250MATCH
  • Wide range of banking options
  • Great reward program
  • Well know brand

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Strong presence in US
  • Wide range of betting options
  • Generous bonus offers

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Easy registration process
  • Great promotions
  • Best Multi interface platform

Get $1000 bonus

Promo Сode:
USSBRF1000
  • Great Promotions
  • Offers Casino, Sportsbook & DFS
  • One of the Largest Gambling Sites in the US

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Wide range of betting options
  • Trustworthy brand
  • Great Promotions

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Wide range of banking options
  • Great reward program
  • Well know brand

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Generous bonus offers
  • Wide range of betting options
  • Strong presence in US

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Easy registration process
  • Best Multi interface platform
  • Great promotions

Get $1000 bonus

Promo Сode:
USSBRF1000
  • Very user-friendly platform
  • Outstanding US sports offers
  • One of the biggest sportsbooks in US

Get $2000 bonus

Promo Сode:
USSB2000

Unibet Sportsbook

Rated 4.7 stars out of 5
4.7
  • Sign-up Bonus
  • Trustworthy brand
  • Great international betting coverage

Get $500 bonus

Promo Сode:
NONE NEEDED
  • Well know brand
  • Wide range of banking options
  • Great reward program

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Generous bonus offers
  • Wide range of betting options
  • Strong presence in US

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Great promotions
  • Best Multi interface platform
  • Easy registration process

Get $1000 bonus

Promo Сode:
USSBRF1000

Sportsbetting.com

Rated 4 stars out of 5
4.0
  • 1X Bonus Playthrough
  • Exciting Daily Promos
  • Fast payouts

Get $150 bonus

Promo Сode:
NONE NEEDED
  • Outstanding US sports offers
  • One of the biggest sportsbooks in US
  • Very user-friendly platform

Get $2000 bonus

Promo Сode:
USSB2000
  • Strong presence in US
  • Wide range of betting options
  • Generous bonus offers

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Very user-friendly platform
  • One of the biggest sportsbooks in US
  • Outstanding US sports offers

Get $2000 bonus

Promo Сode:
USSB2000
  • One of the Largest Gambling Sites in the US
  • Offers Casino, Sportsbook & DFS
  • Great Promotions

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Great Welcome Bonus
  • Top Class Customer Support
  • Both online and land-based sportsbook

Get $250 bonus

Promo Сode:
250MATCH
  • Well know brand
  • Wide range of banking options
  • Great reward program

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Generous bonus offers
  • Strong presence in US
  • Wide range of betting options

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Great promotions
  • Best Multi interface platform
  • Easy registration process

Get $1000 bonus

Promo Сode:
USSBRF1000
  • One of the Largest Gambling Sites in the US
  • Offers Casino, Sportsbook & DFS
  • Great Promotions

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Trustworthy brand
  • Wide range of betting options
  • Great Promotions

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Wide range of banking options
  • Well know brand
  • Great reward program

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Strong presence in US
  • Wide range of betting options
  • Generous bonus offers

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Best Multi interface platform
  • Great promotions
  • Easy registration process

Get $100 free

Promo Сode:
USSBRF1000

Unibet Sportsbook

Rated 4.7 stars out of 5
4.7
  • Great international betting coverage
  • Trustworthy brand
  • Sign-up Bonus

Get $500 bonus

Promo Сode:
NONE NEEDED
  • One of the Largest Gambling Sites in the US
  • Offers Casino, Sportsbook & DFS
  • Great Promotions

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Wide range of banking options
  • Great reward program
  • Well know brand

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Wide range of betting options
  • Generous bonus offers
  • Strong presence in US

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Great promotions
  • Best Multi interface platform
  • Easy registration process

Get $1000 bonus

Promo Сode:
USSBRF1000
  • Very user-friendly platform
  • Outstanding US sports offers
  • One of the biggest sportsbooks in US

Get $2000 bonus

Promo Сode:
USSB2000
  • Offers Casino, Sportsbook & DFS
  • Great Promotions
  • One of the Largest Gambling Sites in the US

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Best Multi interface platform
  • Easy registration process
  • Great promotions

Get $1000 bonus

Promo Сode:
USSBRF1000
  • Generous bonus offers
  • Wide range of betting options
  • Strong presence in US

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Easy registration process
  • Best Multi interface platform
  • Great promotions

Get $1000 bonus

Promo Сode:
USSBRF1000
  • One of the Largest Gambling Sites in the US
  • Offers Casino, Sportsbook & DFS
  • Great Promotions

Get $1000 bonus

Promo Сode:
NONE NEEDED

Betway Sportsbook

Rated 4.4 stars out of 5
4.4
  • Great user experience
  • Well established sportsbook
  • Generous bonus offers

Get $250 bonus

Promo Сode:
NONE NEEDED

Total Prediction

While I do think the Pittsburgh Panthers have an elite defense, they haven’t been tested by an offense quite like Louisville’s yet. Malik Cunningham is a beast of a QB and Javian Hawkins is an even better RB. They’re both protected by an elite offensive line that’s going to put up a nice battle against the Panthers D line. 

The Cardinals defense is obviously nothing special, so I expect Pittsburgh to put up a few scores. I just expect the Cardinals to put up one more two more and for this over to hit with ease. The over is my favorite bet in this game. 

The Pick: Over 53 Final Score Prediction: Louisville 28, Pittsburgh 27
  • New
    nj
  • 1200px
    pa
  • 1200px
    mi
  • 1200px
    wv
  • Indiana
    in
  • 1200px
    co
  • Illinois
    il
  • State
    tn
  • Seal
    va
  • Iowa
    ia
  • Seal
    dc
  • Other
  • Wide range of banking options
  • Well know brand
  • Great reward program

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Generous bonus offers
  • Wide range of betting options
  • Strong presence in US

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Great promotions
  • Best Multi interface platform
  • Easy registration process

Get $1000 bonus

Promo Сode:
USSBRF1000

Bet365 Sportsbook

Rated 4.8 stars out of 5
4.8
  • World biggest sportsbook
  • Great live betting
  • Top class user experience

Get $500 bonus

Promo Сode:
USSB500
  • Wide Range of Banking Options
  • Generous Bonus
  • Great Loyalty Program

Get $250 bonus

Promo Сode:
USSB
  • Strong presence in US
  • Wide range of betting options
  • Generous bonus offers

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Best Multi interface platform
  • Easy registration process
  • Great promotions

Get $1000 bonus

Promo Сode:
USSBRF1000
  • Generous Bonus
  • Great Loyalty Program
  • Wide Range of Banking Options

Get $250 bonus

Promo Сode:
USSB

Unibet Sportsbook

Rated 4.7 stars out of 5
4.7
  • Great international betting coverage
  • Trustworthy brand
  • Sign-up Bonus

Get $500 bonus

Promo Сode:
NONE NEEDED
  • Great Promotions
  • Offers Casino, Sportsbook & DFS
  • One of the Largest Gambling Sites in the US

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Well know brand
  • Great reward program
  • Wide range of banking options

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Wide range of betting options
  • Generous bonus offers
  • Strong presence in US

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Best Multi interface platform
  • Easy registration process
  • Great promotions

Get $1000 bonus

Promo Сode:
USSBRF1000
  • Offers Casino, Sportsbook & DFS
  • One of the Largest Gambling Sites in the US
  • Great Promotions

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Great Welcome Bonus
  • Both online and land-based sportsbook
  • Top Class Customer Support

Get $250 bonus

Promo Сode:
250MATCH
  • Wide range of banking options
  • Great reward program
  • Well know brand

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Wide range of betting options
  • Generous bonus offers
  • Strong presence in US

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Great promotions
  • Best Multi interface platform
  • Easy registration process

Get $1000 bonus

Promo Сode:
USSBRF1000
  • One of the Largest Gambling Sites in the US
  • Offers Casino, Sportsbook & DFS
  • Great Promotions

Get $1000 bonus

Promo Сode:
NONE NEEDED
  • Great Promotions
  • Wide range of betting options
  • Trustworthy brand

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF
  • Well know brand
  • Great reward program
  • Wide range of banking options

Get $5000 bonus

Promo Сode:
SPORTSBONUSRF

FanDuel Sportsbook

Rated 4.5 stars out of 5